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    ProteinGym Hard

    🏆 Leaderboard

    As of September 1, 2026, Claude Mythos 5.1 is #1 for ProteinGym Hard at 49.3%. Ranked by the ProteinGym Hard score 1 models in this index have a published ProteinGym Hard score. ProteinGym Hard leaderboard with live API prices. ProteinGym Hard — rank-correlation of mutation effect predictions against lab data.

    Updated September 1, 2026347 models36 providers
    Claude Mythos 5.1
    Anthropic · Proprietary
    		49.3%$60.00
    ChatGPT-4o Latest
    OpenAI · Proprietary
    		—$12.50
    Claude 3 Haiku
    Anthropic · Proprietary
    		—$1.50
    Claude 3 Opus
    Anthropic · Proprietary
    		—$90.00
    Claude 3 Sonnet
    Anthropic · Proprietary
    		—$18.00
    Claude 3.5 Haiku
    Anthropic · Proprietary
    		—$4.80
    Claude 3.5 Sonnet
    Anthropic · Proprietary
    		—$18.00
    Claude 3.5 Sonnet
    Anthropic · Proprietary
    		—$18.00
    Claude 3.7 Sonnet
    Anthropic · Proprietary
    		—$18.00
    Claude Fable 5
    Anthropic · Proprietary
    		—$60.00
    Claude Fable 5.1
    Anthropic · Proprietary
    		—$60.00
    Claude Haiku 4.5
    Anthropic · Proprietary
    		—$6.00
    Claude Mythos 5
    Anthropic · Proprietary
    		—$60.00
    Claude Mythos Preview
    Anthropic · Proprietary
    		—$60.00
    Claude Opus 4
    Anthropic · Proprietary
    		—$90.00
    Claude Opus 4.1
    Anthropic · Proprietary
    		—$90.00
    Claude Opus 4.5
    Anthropic · Proprietary
    		—$30.00
    Claude Opus 4.6
    Anthropic · Proprietary
    		—$30.00
    Claude Opus 4.7
    Anthropic · Proprietary
    		—$30.00
    Claude Opus 4.8
    Anthropic · Proprietary
    		—$30.00
    Claude Opus 5
    Anthropic · Proprietary
    		—$30.00
    Claude Sonnet 4
    Anthropic · Proprietary
    		—$18.00
    Claude Sonnet 4.5
    Anthropic · Proprietary
    		—$18.00
    Claude Sonnet 4.6
    Anthropic · Proprietary
    		—$18.00
    Claude Sonnet 5
    Anthropic · Proprietary
    		—$12.00
    Codestral-22BOSS
    Mistral · Open Source · via Mistral AI
    		—$1.20
    Command A+OSS
    Cohere · Open Source
    		—$12.50
    Command R+OSS
    Cohere · Open Source
    		—$1.25
    Composer 2
    Cursor · Proprietary
    		—$3.00
    Composer 2 Fast
    Cursor · Proprietary
    		—$9.00
    DeepSeek R1 Distill Llama 70BOSS
    DeepSeek · Open Source
    		—$0.50
    DeepSeek R1 Distill Qwen 32BOSS
    DeepSeek · Open Source
    		—$0.30
    DeepSeek VL2OSS
    DeepSeek · Open Source · via Replicate
    		—$2.80
    DeepSeek VL2 SmallOSS
    DeepSeek · Open Source · via Replicate
    		—$1.70
    DeepSeek VL2 TinyOSS
    DeepSeek · Open Source · via Replicate
    		—$0.90
    DeepSeek-R1OSS
    DeepSeek · Open Source
    		—$2.74
    DeepSeek-R1-0528OSS
    DeepSeek · Open Source
    		—$2.74
    DeepSeek-V2.5OSS
    DeepSeek · Open Source
    		—$0.42
    DeepSeek-V3OSS
    DeepSeek · Open Source
    		—$1.37
    DeepSeek-V3 0324OSS
    DeepSeek · Open Source
    		—$1.42
    DeepSeek-V3.1OSS
    DeepSeek · Open Source
    		—$1.27
    DeepSeek-V3.2OSS
    DeepSeek · Open Source · via OpenRouter
    		—$0.57
    DeepSeek-V3.2 (Non-thinking)OSS
    DeepSeek · Open Source
    		—$0.70
    DeepSeek-V3.2-ExpOSS
    DeepSeek · Open Source
    		—$0.68
    DeepSeek-V4-Flash-0423OSS
    DeepSeek · Open Source
    		—$0.30
    DeepSeek-V4-Flash-0731OSS
    DeepSeek · Open Source
    		—$1.76
    DeepSeek-V4-Flash-MaxOSS
    DeepSeek · Open Source
    		—$0.42
    DeepSeek-V4-Flash-Vision-Exp
    DeepSeek · Proprietary
    		—$0.88
    DeepSeek-V4-Pro-0813OSS
    DeepSeek · Open Source
    		—$5.28
    DeepSeek-V4-Pro-MaxOSS
    DeepSeek · Open Source
    		—$5.22
    Showing 1–50 of 347 models

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    The index

    All Large Language Models

    347 models across 36 providers. Search or jump to a lab — every model page stays linked here.

    OpenAI52Anthropic24Google34Cursor2xAI17DeepSeek20MiniMax7Qwen55AI21 Labs2Amazon7Baidu2ByteDance4Cohere4IBM2Inception1inclusionAI1LG AI Research1Liquid AI2Meituan4Meta12Microsoft9Mistral26Moonshot AI11Nous Research1NVIDIA9OpenBMB1Poolside2Sakana AI1Sarvam AI2StepFun2Tencent1Thinking Machines1Unisound1Upstage1Xiaomi5Z AI21

    Baidu

    2 models
    ERNIE 5.0ERNIE 4.5

    Inception

    1 models
    Mercury 2

    inclusionAI

    1 models
    Ling-3.0-flash

    LG AI Research

    1 models
    K-EXAONE-236B-A23B

    Liquid AI

    2 models
    LFM2.5-VL-3BLFM2.5-2.6B

    Nous Research

    1 models
    Hermes 3 70B

    OpenBMB

    1 models
    MiniCPM-SALA

    Sakana AI

    1 models
    Sakana Namazu

    Sarvam AI

    2 models
    Sarvam-105BSarvam-30B

    Tencent

    1 models
    Hy3

    Thinking Machines

    1 models
    Inkling-Small

    Unisound

    1 models
    U2

    Upstage

    1 models
    Solar Pro 4

    Which model leads ProteinGym Hard right now?

    As of September 1, 2026, Claude Mythos 5.1 by Anthropic is #1 for ProteinGym Hard at 49.3%. Ranked by the ProteinGym Hard score This board also tracks ProteinGym Hard. This proteingym hard leaderboard ranks models by ProteinGym Hard. Scores come from public evals. Prices are the live API rates in the table above.

    Sources: OpenAI API pricing (https://developers.openai.com/api/docs/pricing); Anthropic Claude API pricing (https://platform.claude.com/docs/en/about-claude/pricing); Gemini API pricing (https://ai.google.dev/gemini-api/docs/pricing)

    Top 1 for proteingym hard. Ranked by the ProteinGym Hard score Input and output are dollars per million tokens.
    RankModelProteinGym HardInput /MOutput /M
    1Claude Mythos 5.149.3%$10.00$50.00

    Related LLM leaderboards

    LLM LeaderboardCodingMathAgenticReasoningWritingScienceFinanceLong ContextVisionOpen Source

    Individual benchmark pages

    Rank one eval at a time. All LLM benchmarks.

    HLESWE BenchHumanity's Last Exam (No Tools)Humanity's Last Exam (With Tools)Terminal-Bench 2.0Terminal-BenchTerminal-Bench 2.1Terminal-Bench 2Terminal-Bench 3.0ARC-AGI-1 Verified

    ProteinGym Hard FAQ

    Who ranks #1 on the ProteinGym Hard leaderboard?

    As of September 1, 2026, Claude Mythos 5.1 by Anthropic ranks #1 on ProteinGym Hard at 49.3%. API pricing is $10.00/M input and $50.00/M output.

    Which proteingym hard model is the cheapest?

    Claude Mythos 5.1 currently leads ProteinGym Hard and is also the cheapest scored model on this page, at $10.00/M input and $50.00/M output ($60.00 blended).

    Should I always pick the #1 ProteinGym Hard model?

    Not automatically. Claude Mythos 5.1 leads ProteinGym Hard, but a cheaper scored model can be the better production choice if the quality gap is small. Use the table to weigh ProteinGym Hard against input/output price, context window, and related evals.

    How often is the ProteinGym Hard leaderboard updated?

    Scores and API prices on this page are refreshed from published evals and provider rates. The snapshot is labeled September 1, 2026. Treat it as a current index, not a one-off blog post.

    What is ProteinGym Hard?

    ProteinGym Hard — rank-correlation of mutation effect predictions against lab data. This page ranks models that have published a ProteinGym Hard score, with live API token prices on the same row.

    Where is the ProteinGym Hard leaderboard?

    This page is the ProteinGym Hard leaderboard. Models are sorted by ProteinGym Hard, with input and output token prices on the same row so you can weigh score against cost. Official boards often omit price; that comparison is the point of this index.

    How is this ProteinGym Hard ranking different from the official board?

    Official eval pages own the methodology. This page keeps the published ProteinGym Hard score next to live API $/M so you can pick a production SKU, not only a trophy number.